Development of a 3D-Bioprinted Ulcerative Colitis Model for Improved Clinical Translation
London South Bank University, London, UK
Scheduled Start - May 2026
I have been selected to join the research group supervised by Dr. Julia Mantaj to solve a major problem in drug testing. Currently, many gut treatments fail in humans even after working in mice because animal models are not accurate enough.
3D Bioprinting: Building a living, structural model of the human colon using bio-inks and human cells.
Disease Modelling: Inducing "Ulcerative Colitis" in this model to mimic real patient conditions.
Drug Testing: Using this model to test if new treatments can successfully stick to the gut wall and heal inflammation.
Glasgow Caledonian University, Glasgow, UK
June 2024 – August 2024
I led a drug discovery project from the computer screen to the laboratory bench. My focus was on the Connexin26 G12R protein mutation, a difficult target in cancer therapy.
In Silico (Computer) Work: I used computer modelling to predict how potential drug molecules would interact with the protein structure.
Lab Validation: I moved into the wet lab to test these predictions using cell-based assays.
My work was graded at a distinction level and contributed to my award as the "Best Overall Student" on the programme.
National Biosafety Management Agency, Abuja, Nigeria
December 2021 – November 2022
I worked in the GMO Detection Laboratory, ensuring that agricultural and processed food products met national safety standards.
High-Volume Screening: I screened over 500 samples for Genetically Modified Organisms (GMOs) using PCR technology.
Accuracy: I achieved a ~90% accuracy rate in my results.
Reporting: I provided data for over 30 regulatory reports used for national biosafety monitoring.
NAFDAC, Kaduna, Nigeria
September 2018 – April 2019
My foundation in science began here, focusing on public health and consumer safety.
Safety Testing: I conducted microbial tests on food, water, and pharmaceutical products to ensure they were safe for public consumption.
Compliance: I learned to strictly adhere to Good Laboratory Practice (GLP) and regulatory guidelines.
Institution: London South Bank University, UK
Thesis Title: Development of a 3D-Bioprinted Ulcerative Colitis Model for Improved Clinical Translation of Treatment Efficacy.
Institution: Glasgow Caledonian University, Glasgow, UK
Thesis Project: Investigated the functional impact of the GJB2 (Connexin 26) G12R mutation on cellular function using molecular cloning, mammalian cell culture, transfection, and protein structure prediction (AlphaFold, iCn3D).
Grade: Distinction
Institution: Benue State University, Makurdi, Nigeria
Thesis Project: Evaluated the antimicrobial activity of an herbal preparation versus selected antibiotics against wound bacteria using Soxhlet extraction, disc diffusion assays, and Minimum Inhibitory Concentration (MIC) determination.
Cell Culture: Mammalian Cell Culture (Maintenance, Counting, Seeding), Transfection (Lipofection), and Viral Stock Preparation.
Molecular Analysis: Western Blotting, SDS-PAGE, and Microscopy (Immunofluorescence & Confocal).
Genetics: PCR, qPCR, RT-qPCR, and Molecular Cloning (Plasmid Design, Restriction Digest, Ligation).
Susceptibility Testing: Antimicrobial Susceptibility Testing (AST), Disc Diffusion, and Minimum Inhibitory Concentration (MIC).
Culture Techniques: Microbial Culture (Broth, Agar), Serial Dilution, Colony Counting, and Bacterial Identification.
Lab Operations: Soxhlet Extraction, Aseptic Technique, and Clinical Sample Processing (Wound Swabs).
Structural Biology: Protein Structure Prediction (AlphaFold) and Visualisation (iCn3D).
Bioinformatics: Sequence analysis and visualisation using SnapGene.
Data Science: Statistical Analysis (GraphPad Prism, Jamovi), R Programming, and Image Analysis (ImageJ).
Associate Member (AMRSB)—Royal Society of Biology
Full Member (MNSM)—Nigerian Society for Microbiology
Member—Nigerian Society of Biochemistry and Molecular Biology (NSBMB)
(Coming Soon)
I look forward to sharing my findings from my upcoming PhD research in this section.